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Onglyza Heart Attack and Cancer Risks

Details on side effects, claims, and more from our Onglyza lawyer | Helping those you suffered injuries, like heart attack, with their Onglyza lawsuit

Several type 2 diabetes drugs, including Onglyza, Actos and Byetta, have been linked to potential heart failure and pancreatitis. A higher incidence of these medical complications moved many patients to file complaints against the manufacturer, AstraZeneca.

Diabetes drug saxagliptin, marketed as Onglyza and Kombiglyze XR, as well as a group of medicines under generic name alogliptin, increase the risk of heart failure, but their makers didn’t warn about it until the Food and Drug Administration (FDA) and required AstraZenec to place a warning on the label in 2016.

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Two medical trials in 2015 showed that patients who received saxagliptin or alogliptin containing medicines had more hospitalizations due to heart failure compared to patients who received an inactive treatment called a placebo.

Greg Jones Law has sued many major drug manufacturers for failing to warn of the dangers of their drugs. To find out if you have a case against the makers of Onglyza, contact us today for a free case evaluation.


Onglyza has been popular among diabetics because it does not lead to weight gain, but has several risks and adverse effects that could be deadly, particularly for those who already have cardiovascular or liver damage. This risk has been downplayed by the drug manufacturer AstraZeneca.

Saxagliptin and alogliptin are part of the class of prescription medicines called dipeptidyl peptidase-4 (DPP-4) inhibitors, which are used to control high blood sugar (along with diet and exercise) in adults with type 2 diabetes. These medicines lower blood sugar by helping the body increase the level of the hormone insulin after meals and keep blood sugar levels stable.

Medical studies have shown the potential to develop the following serious medical conditions:

  • Inflammation of the pancreas (pancreatitis)
  • Severe joint pain (arthralgia)
  • Pancreatic cancer
  • Thyroid cancer
  • Allergic reactions
  • Low blood sugar (hypoglycemia)

Medical studies continue to surface providing evidence linking the drug to the increased risk of pancreatic cancer. A study reviewed by the FDA in 2014 uncovered a possible increased risk of pancreatitis and pre-cancerous signs in the pancreas of patients taking Onglyza and similar drugs.

While taking Onglyza, patients should be aware of possible thyroid cancer symptoms, including:

  • Lump or nodule on the lower front and center part of the neck
  • Swelling on the neck
  • Changes in voice
  • Unexplained coughing or hoarseness
  • Problems breathing or swallowing
  • Enlarged or painful lymph nodes in the neck

Patients taking these medicines should not stop them without first talking to your health care professionals, but should be aware of severe signs or symptoms that don’t go away, which merits an immediate call to the doctor.

If you take Onglyza, you should contact your doctor right away if you develop the signs and symptoms of heart failure, such as:

  • Unusual shortness of breath during daily activities
  • Trouble breathing when lying down
  • Tiredness, weakness, or fatigue
  • Weight gain with swelling in the ankles, feet, legs, or stomach

Patients who suffered heart failure while on Onglyza are bringing suits claiming AstraZeneca did not properly warn about all the medicine’s side effects. The FDA did not start requiring the drug maker to adequately warn of the side effects until 2016. However, the drug was on the market long before.


For most people, taking legal action against a pharmaceutical company can seem daunting, unless you have an experienced lawyer on your side, seeking just compensation for your suffering and losses.

Greg Jones Law has successfully defended patients against major drug manufacturers and has the means to represent clients throughout the United States in pharmaceutical litigation.

If you or someone you know has suffered after taking a dangerous drug, the best thing you can do is call us to find out if you have a case. Call 855-566-3752 or contact us online today for a free consultation with an Onglyza lawyer. We’re here to help!

Put an experienced Onglyza lawyer on your side. Contact us today!

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